Wellbutrin Xl, also known as bupropion, is a prescription drug used to address major depressive disorder (MDD), prevent seasonal affective disorder (SAD), and aid in smoking cessation. To ensure its safe and effective use, it’s crucial to be aware of specific precautions and drug interactions. According to Mental Health America, major depression affects over 21 million American adults each year. This fact makes understanding the effect of Wellbutrin on patients even more important. Let’s understand the precautions, its uses, side effects, and drugs to avoid while you take Wellbutrin Xl 300 Mg.

What Is Wellbutrin?

Wellbutrin Xl (bupropion) is a medication that is used to treat patients who suffer from seasonal affective disorder or depression. It helps people with these conditions feel better. There are chemicals in your brain known as neurotransmitters that affect your mood, emotions, and memory. Wellbutrin increases two of these neurotransmitters, norepinephrine and dopamine. 

Wellbutrin Xl comes in two forms: 150mg and 300mg. Wellbutrin 300 mg is more commonly used for treating MDD and SAD.

What Is Wellbutrin Xl 300 Mg Used For?

Wellbutrin Xl 300 Mg is recommended for patients with:

  • Depression
  • Smoking Cessation
  • Depressive Psychosis
  • Arteriosclerotic Dementia with depressive Features
  • SAD (Seasonal Affective Disorder)

Precautions to Take While You Are on Wellbutrin Medication

It is essential to always follow your healthcare provider’s guidance and the medication’s label instructions when taking Wellbutrin Xl. You should be aware of potential side effects and interactions to ensure the safe and effective use of the medication. Additionally, if you want to buy genuine and affordable medication, order from Wellbutrin Canadian pharmacy. Here are some precautions you should keep in mind when you are on Wellbutrin.

  • It’s highly advisable to avoid alcohol while you are taking Wellbutrin Xl 300 Mg. Alcohol can interact with this medication and increase the possibility of seizures, as Wellbutrin and alcohol both can lower the seizure threshold.
  • Wellbutrin can cause dizziness, which can affect your ability to drive or work with heavy machinery. Avoid activities that require concentration till you understand how this medication affects you.
  • If you’ve had seizures before or are more likely to have them, talk to your doctor. Wellbutrin Xl might not be the right choice for you if you have a history of seizures.
  • If you are pregnant or breastfeeding, consult your healthcare provider before taking Wellbutrin Xl. The potential risks and benefits must be carefully considered in these situations.
  • Grapefruit and grapefruit juice can interact with Wellbutrin and affect your metabolism. It’s generally recommended to avoid them while taking the medication.
  • Wellbutrin Xl can cause difficulty sleeping if taken too late in the day. Hence, it’s recommended to take it in the morning to minimize sleep disturbances.
  •  Limit the consumption of caffeine or energy drinks, as they can lead to increased anxiety or restlessness.

Medication You Should Avoid While on Wellbutrin

Taking bupropion with certain medications can increase the chances of experiencing side effects. These drugs include:

Antidepressants: Antidepressants like venlafaxine, fluoxetine, paroxetine, imipramine, desipramine, nortriptyline, or sertraline can cause seizures if combined with Wellbutrin 300mg. If these medications are absolutely necessary, your doctor may keep you on a low dosage.

Antipsychotics: Antipsychotics (medication for psychosis) like haloperidol or thioridazine can cause seizures if you are taking them with Wellbutrin Xl 300mg. If these drugs are needed, your doctor may start with a low dosage.

[Psychosis: When a person’s mind doesn’t work quite right, and they start to believe or see things that are not real.]

Beta-blockers: Beta-blockers such as metoprolol can cause low blood pressure. Your health provider may reduce your dosage of these medicines if they’re taken with bupropion.

[Beta blockers are medicines that are used to block the effects of stress hormone called adrenaline]

Antiarrhythmics: Anti-arrhythmics (used to stabilize heart rhythms) such as propafenone or flecainide can cause changes in your heartbeat if you are taking Wellbutrin Xl 300 Mg.

Levodopa and Amantadine: These drugs are advised for patients with Parkinson’s disease. If taken with bupropion, they can cause agitation, restlessness, loss of body movements, loss of balance, dizziness, and trouble while walking.

Blood thinner drugs: If you use ticlopidine or clopidogrel (used for thinning blood) along with bupropion, your doctor may modify your Wellbutrin Xl 300mg dosage so that the levels of bupropion in your body don’t get too high.

Benzodiazepines: Using alprazolam or clonazepam (medicines for treating anxiety and insomnia) with 300 mg Wellbutrin Xl can increase the risk of seizures. It also increases if you stop taking these drugs suddenly. Talk to your doctor before taking them.

When Do Doctors Not Prescribe Wellbutrin to the Patients?

Doctors might not prescribe Wellbutrin XL 300 mg in certain situations. Let us find out the conditions under which this medication is not recommended.

  • Doctors will not prescribe Wellbutrin Xl 300mg to you if you have been diagnosed with a certain eating disorder, such as anorexia or bulimia.
  • Doctors will not prescribe Wellbutrin 300 mg to you if you have recently suddenly stopped drinking alcohol or taking certain drugs.
  • Doctors will not prescribe Wellbutrin to you if you’re taking or have recently taken a drug known as monoamine oxidase inhibitor (MAOI).

[Fact: You should not use an MAOI 14 days before or after you take Wellbutrin.]

Side Effects of Wellbutrin Xl 300 Mg

Possible side effects of Wellbutrin can be life-threatening and can cause:

  • Severe depression
  • Suicidal thoughts and behavior
  • Visual problem
  • Severe allergic reactions
  • Homicidal thoughts
  • Neuropsychiatric diseases
  • Panic Attacks
  • Seizures
  • High blood pressure or hypertension
  • Heart problems
  • Angle-closure glaucoma
  • Liver problems

Moreover, to save yourself from the side effects of low-quality medicines, it is important to order from the best Canadian online pharmacy to ensure that you receive safe, authentic, and high-quality medications. It’s an essential step in managing your health effectively while minimizing risks.


If you are using Wellbutrin Xl 300 Mg, it’s vital to exercise caution and follow precautions to ensure both the quality and the effectiveness of your treatment. This medication can be valuable in managing conditions like depression and seasonal affective disorder. Remember, if you buy Wellbutrin from Canada, take the precautions mentioned in this article, and work closely with your healthcare provider, you can definitely achieve better mental health and well-being.

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